Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal, Anup; Parai, Maloy K; Shetty, Nishant; Wallis, Deeann; Woolhiser, Lisa; Hastings, Courtney; Dutta, Noton K; Galaviz, Stacy; Dhakal, Ramesh C; Shrestha, Rupesh; Wakabayashi, Shoko; Walpole, Chris; Matthews, David; Floyd, David; Scullion, Paul; Riley, Jennifer; Epemolu, Ola; Norval, Suzanne; Snavely, Thomas; Robertson, Gregory T; Rubin, Eric J; Ioerger, Thomas R; Sirgel, Frik A; van der Merwe, Ruben; van Helden, Paul D; Keller, Peter; Böttger, Erik C; Karakousis, Petros C; Lenaerts, Anne J; Sacchettini, James C.

Cell ; 170(2): 249-259.e25, 2017 Jul 13.

Artigo em Inglês | MEDLINE | ID: mdl-28669536

2.

Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing.

Zhang, Yanjia J; Reddy, Manchi C; Ioerger, Thomas R; Rothchild, Alissa C; Dartois, Veronique; Schuster, Brian M; Trauner, Andrej; Wallis, Deeann; Galaviz, Stacy; Huttenhower, Curtis; Sacchettini, James C; Behar, Samuel M; Rubin, Eric J.

Cell ; 155(6): 1296-308, 2013 Dec 05.

Artigo em Inglês | MEDLINE | ID: mdl-24315099

3.

Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus.

Commins, Nicoletta; Sullivan, Mark R; McGowen, Kerry; Koch, Evan M; Rubin, Eric J; Farhat, Maha.

Proc Natl Acad Sci U S A ; 120(22): e2302033120, 2023 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-37216535

4.

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Johnson, Eachan O; LaVerriere, Emily; Office, Emma; Stanley, Mary; Meyer, Elisabeth; Kawate, Tomohiko; Gomez, James E; Audette, Rebecca E; Bandyopadhyay, Nirmalya; Betancourt, Natalia; Delano, Kayla; Da Silva, Israel; Davis, Joshua; Gallo, Christina; Gardner, Michelle; Golas, Aaron J; Guinn, Kristine M; Kennedy, Sofia; Korn, Rebecca; McConnell, Jennifer A; Moss, Caitlin E; Murphy, Kenan C; Nietupski, Raymond M; Papavinasasundaram, Kadamba G; Pinkham, Jessica T; Pino, Paula A; Proulx, Megan K; Ruecker, Nadine; Song, Naomi; Thompson, Matthew; Trujillo, Carolina; Wakabayashi, Shoko; Wallach, Joshua B; Watson, Christopher; Ioerger, Thomas R; Lander, Eric S; Hubbard, Brian K; Serrano-Wu, Michael H; Ehrt, Sabine; Fitzgerald, Michael; Rubin, Eric J; Sassetti, Christopher M; Schnappinger, Dirk; Hung, Deborah T.

Nature ; 571(7763): 72-78, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-31217586

5.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.

Koh, Eun-Ik; Oluoch, Peter O; Ruecker, Nadine; Proulx, Megan K; Soni, Vijay; Murphy, Kenan C; Papavinasasundaram, Kadamba; Reames, Charlotte J; Trujillo, Carolina; Zaveri, Anisha; Zimmerman, Matthew D; Aslebagh, Roshanak; Baker, Richard E; Shaffer, Scott A; Guinn, Kristine M; Fitzgerald, Michael; Dartois, Véronique; Ehrt, Sabine; Hung, Deborah T; Ioerger, Thomas R; Rubin, Eric J; Rhee, Kyu Y; Schnappinger, Dirk; Sassetti, Christopher M.

Proc Natl Acad Sci U S A ; 119(15): e2201632119, 2022 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-35380903

6.

Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity.

Rego, E Hesper; Audette, Rebecca E; Rubin, Eric J.

Nature ; 546(7656): 153-157, 2017 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-28569798

7.

Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice.

Martinot, Amanda J; Blass, Eryn; Yu, Jingyou; Aid, Malika; Mahrokhian, Shant H; Cohen, Sara B; Plumlee, Courtney R; Larocca, Rafael A; Siddiqi, Noman; Wakabayashi, Shoko; Gardner, Michelle; Audette, Rebecca; Devorak, Anne; Urdahl, Kevin B; Rubin, Eric J; Barouch, Dan H.

PLoS Pathog ; 16(12): e1009096, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33315936

8.

ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.

Kester, Jemila C; Kandror, Olga; Akopian, Tatos; Chase, Michael R; Zhu, Junhao; Rubin, Eric J; Goldberg, Alfred L; Fortune, Sarah M.

J Bacteriol ; 203(4)2021 01 25.

Artigo em Inglês | MEDLINE | ID: mdl-33229461

9.

Making the Worm Turn.

Rubin, Eric J.

N Engl J Med ; 388(20): 1908-1910, 2023 May 18.

Artigo em Inglês | MEDLINE | ID: mdl-37195950

10.

Shortening Tuberculosis Treatment - A Strategic Retreat.

Dartois, Véronique; Rubin, Eric J.

N Engl J Med ; 388(10): 939-941, 2023 Mar 09.

Artigo em Inglês | MEDLINE | ID: mdl-36807402

11.

Audio Interview: Ending the Covid-19 Public Health Emergency.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(13): e53, 2023 Mar 30.

Artigo em Inglês | MEDLINE | ID: mdl-36988604

12.

Audio Interview: The Future of Covid-19 Research.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(11): e39, 2023 Mar 16.

Artigo em Inglês | MEDLINE | ID: mdl-36920766

13.

Audio Interview: When to Get a Second Covid-19 Booster Shot.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(15): e64, 2023 Apr 13.

Artigo em Inglês | MEDLINE | ID: mdl-37043659

14.

Audio Interview: Ending the Covid-19 Emergency.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(19): e72, 2023 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-37163631

15.

Audio Interview: The Expanding Arsenal of Oral Agents to Treat Covid-19.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(1): e7, 2023 01 05.

Artigo em Inglês | MEDLINE | ID: mdl-36599068

16.

Audio Interview: Weighing the Protective Value of Covid-19 Infection.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(3): e13, 2023 01 19.

Artigo em Inglês | MEDLINE | ID: mdl-36652363

17.

Audio Interview: Covid-19 Vaccines and New Viral Variants.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(2): e8, 2023 01 12.

Artigo em Inglês | MEDLINE | ID: mdl-36630630

18.

Audio Interview: Updating and Standardizing Covid-19 Vaccines.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(5): e21, 2023 02 02.

Artigo em Inglês | MEDLINE | ID: mdl-36724337

19.

Audio Interview: The Path Forward for Covid-19 Therapeutics.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(9): e36, 2023 Mar 02.

Artigo em Inglês | MEDLINE | ID: mdl-36856628

20.

Audio Interview: The Lasting Effects of Covid-19.

Rubin, Eric J; Baden, Lindsey R; Morrissey, Stephen.

N Engl J Med ; 388(21): e76, 2023 May 25.

Artigo em Inglês | MEDLINE | ID: mdl-37224206

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Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing.

Mutation rates and adaptive variation among the clinically dominant clusters of Mycobacterium abscessus.

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.

Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity.

Protective efficacy of an attenuated Mtb ΔLprG vaccine in mice.

ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.

Making the Worm Turn.

Shortening Tuberculosis Treatment - A Strategic Retreat.

Audio Interview: Ending the Covid-19 Public Health Emergency.

Audio Interview: The Future of Covid-19 Research.

Audio Interview: When to Get a Second Covid-19 Booster Shot.

Audio Interview: Ending the Covid-19 Emergency.

Audio Interview: The Expanding Arsenal of Oral Agents to Treat Covid-19.

Audio Interview: Weighing the Protective Value of Covid-19 Infection.

Audio Interview: Covid-19 Vaccines and New Viral Variants.

Audio Interview: Updating and Standardizing Covid-19 Vaccines.

Audio Interview: The Path Forward for Covid-19 Therapeutics.

Audio Interview: The Lasting Effects of Covid-19.